Key result
Patients with lone paroxysmal atrial fibrillation had a significantly greater mean atrial conduction delay zone (50 vs 34 ms) and shorter atrial effective refractory period compared to controls.
Why the study?
Do patients with lone paroxysmal atrial fibrillation exhibit abnormalities in atrial electrophysiological properties compared to controls?
Case-Control (n=120)
Do patients with lone paroxysmal atrial fibrillation exhibit abnormalities in atrial electrophysiological properties compared to controls?
Patients with lone paroxysmal atrial fibrillation demonstrate intrinsic electrophysiological abnormalities, including shorter refractoriness and greater conduction delay, which may predispose them to arrhythmias even without underlying structural heart disease.
There is a greater conduction delay of the atrium and shorter refractoriness in patients with lone PAF. Patients without underlying causes for the development of PAF exhibit abnormalities in the electrophysiological properties of the atrium.
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Centurión et al. (2010) conducted a case-control in Lone Paroxysmal Atrial Fibrillation (n=120). Lone Paroxysmal Atrial Fibrillation vs. Patients without a history of AF was evaluated on Atrial conduction delay (CD) zone (p=<0.01). Patients with lone paroxysmal atrial fibrillation had a significantly greater mean atrial conduction delay zone (50 vs 34 ms) and shorter atrial effective refractory period compared to controls.
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