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Oral administration of 5-hydroxytryptophan (5-HTP, 200 mg), a precursor of serotonin, significantly increased plasma human prolactin (hPr) levels in 18 of 21 normal subjects examined. Concomitant intravenous infusion of cyproheptadine (5 mg), a serotonin antagonist, significantly blunted the plasma hPr response to 5-HTP. These results suggest that the serotonergic mechanism is involved in the regulation of prolactin secretion in man.
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Kato et al. (1974) studied this question.
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