Transcriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease

Figures

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  Figure 1. Cardiopulmonary EC heterogeneity in the steady state. Conceptual overview of cardiopulmonary EC heterogeneity in the steady state showing the main structure, functions, and signature genes of cardiac arterial, cardiac venous, cardiac capillary, endocardial, pulmonary arterial, pulmonary venous, and pulmonary capillary ECs. Cap1, general capillary EC; C1, capillary EC subcluster 1; C2, capillary EC subcluster 2; Cap2, aerocyte; NO, nitric oxide; O2, oxygen.

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  Figure 2. ECs as immune regulators in pulmonary health and disease. Conceptual overview of immunomodulatory functions in healthy and diseased lung ECs. The schematic represents signature genes and immune-regulatory molecules and mechanisms in the healthy pulmonary arterial, pulmonary venous, and pulmonary capillary ECs (top) and in their diseased state (bottom). aCap/Cap2, aerocyte; ACKR1, atypical chemokine receptor 1; CLDN10, Claudin 10; COL15A1, collagen type XV α 1; FBLIM1, filamin binding LIM protein 1; gCap/Cap1, general capillary cell; GJA4, gap junction protein α 4; GJA5, gap junction protein α 5; ICAM1, intercellular adhesion molecule 1; VCAM1, vascular cell adhesion molecule 1; vWF, von Willebrand Factor.

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  Figure 3. ECs as immune regulators in cardiac health and disease. Conceptual overview of immunomodulatory functions in healthy and diseased cardiac ECs. The schematic represents signature genes and immune-regulatory molecules and mechanisms in the healthy pulmonary arterial, pulmonary venous, pulmonary capillary, and endocardial ECs (top) and in their diseased state (bottom). ACKR1, atypical chemokine receptor 1; Cap EC, capillary EC; ICAM1, intercellular adhesion molecule 1; VCAM1, vascular cell adhesion molecule 1; vWF, von Willebrand Factor.