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May 1, 1997Journal of Biological ChemistryOpen Access

The MEKK-JNK Pathway Is Stimulated by α1-Adrenergic Receptor and Ras Activation and Is Associated with in Vitro and in Vivo Cardiac Hypertrophy

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Population

Neonatal rat ventricular myocytes (in vitro) and mice overexpressing oncogenic Ras (in vivo)

Design

Preclinical

Authors

MRM. Teresa RamirezUniversity of California, San FranciscoVSValerie P. SahUniversity of California, San DiegoXZXiaolan ZhaoUniversity of Electronic Science and Technology of China

Discussion

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Overview

May identify antihypertrophic targets; leaves open translation from animal models to patients.

Structured PICO

P
Population
Neonatal rat ventricular myocytes (in vitro) and mice overexpressing oncogenic Ras (in vivo)
I
Intervention
alpha1-adrenergic receptor (alpha1-AdrR) stimulation and Ras activation
O
Outcome
c-Jun NH2-terminal kinase (JNK) activation and atrial natriuretic factor (ANF) gene expressionsurrogate

The study identifies the Ras-MEKK-JNK pathway as a key mediator of alpha1-adrenergic receptor-induced cardiac hypertrophy in vitro and in vivo.

Cite This Study

Ramirez et al. (1997) studied this question.

synapsesocial.com/papers/6a11ffc20514fa642cccdbdchttps://doi.org/10.1074/jbc.272.22.14057
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response1991 · 796 citations
  2. 2The Mitogen-activated Protein Kinase Kinase MEK1 Stimulates a Pattern of Gene Expression Typical of the Hypertrophic Phenotype in Rat Ventricular Cardiomyocytes1995 · 161 citations
  3. 3Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.1992 · 169 citations
  4. 4Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes1996 · 222 citations
  5. 5Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)1995 · 212 citations