Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes.

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Population

Primary cultures of neonatal rat ventricular myocytes and adult rat ventricular myocytes (ARVM)

Comparison

Exposure to alpha-adrenergic agonist… vs Unstimulated control ARVM or baseline

Design

Preclinical

Follow-up

up to 24 hours

Authors

Discussion

HB-EGF may mediate myocyte hypertrophy in response to stimuli; leaves open its role in human cardiac remodeling.

Population

Primary cultures of neonatal rat ventricular myocytes and adult rat ventricular myocytes (ARVM)

Intervention

Exposure to alpha-adrenergic agonist phenylephrine, mechanical stimulus (3 Hz electric field stimulation), or exogenous HB-EGF

Comparator

Unstimulated control ARVM or baseline

Outcome

HB-EGF mRNA abundance and cellular protein contentsurrogate

Hypertrophic stimuli induce HB-EGF expression in cardiac myocytes, which may act as an early response gene to facilitate hypertrophic growth.

Perrella et al. (1994) studied this question.

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