What question did this study set out to answer?

To evaluate the prevalence of major medical comorbidities across objectively measured mild, moderate, and severe psoriasis compared with matched individuals without psoriasis.

August 8, 2013JAMA DermatologyOpen Access

Psoriasis Severity and the Prevalence of Major Medical Comorbidity

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Authors

HYHowa YeungEmory University JTJunko TakeshitaUniversity of Pennsylvania NMNehal N. MehtaPreventive Cardiology

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Implication

Cross-sectional study finds higher rates of major medical comorbidities with increasing psoriasis severity in adults, highlighting the need for broader clinical screening.

Key Points

To evaluate the prevalence of major medical comorbidities across objectively measured mild, moderate, and severe psoriasis compared with matched individuals without psoriasis.
Population-based cross-sectional study using United Kingdom electronic medical records including 9,035 patients aged 25 to 64 years with psoriasis and 90,350 age- and practice-matched controls.
Psoriasis severity was classified as mild, moderate, or severe based on body surface area involvement, and major medical comorbidities were assessed using the Charlson comorbidity index.
Mean Charlson comorbidity index scores were significantly higher in mild (0.375 vs 0.347), moderate (0.398 vs 0.342), and severe psoriasis (0.450 vs 0.348) compared with controls (each P < .05).
Psoriasis was associated with increased prevalence of rheumatologic disease (adjusted odds ratio [aOR], 2.04; 95% CI, 1.71-2.42), mild liver disease (aOR, 1.41; 95% CI, 1.12-1.76), peripheral vascular disease (aOR, 1.38; 95% CI, 1.07-1.77), myocardial infarction (aOR, 1.34; 95% CI, 1.07-1.69), and diabetes with systemic complications (aOR, 1.34; 95% CI, 1.11-1.62).
Trend analysis demonstrated significant associations between increasing psoriasis severity and the prevalence of each evaluated comorbid condition (each P < .05).

Cite This Study

Yeung et al. (2013) studied this question.

synapsesocial.com/papers/6a1200eeae8fb4569ad20aae https://doi.org/10.1001/jamadermatol.2013.5015

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Implication

Cross-sectional study finds higher rates of major medical comorbidities with increasing psoriasis severity in adults, highlighting the need for broader clinical screening.

Psoriasis Severity and the Prevalence of Major Medical Comorbidity

Discussion

Member takes

Implication

Key Points

Cite This Study

Psoriasis Severity and the Prevalence of Major Medical Comorbidity

Discussion

Member takes

Implication

Key Points

Cite This Study

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