Key result
Vascular cells enhance human cardiac organoid maturation and contractile force via LAMA5 and PDGFRβ signaling.
Why the study?
Crosstalk between cardiac cells is critical for heart performance, motivating the optimization of human cardiac organoids to incorporate vascular cell populations.
Does the inclusion of vascular cells improve the maturation and contractile force of human cardiac organoids?
Population
Human cardiac organoids
Comparison
Inclusion of vascular populations vs organoids lacking vascular cells
Design
In vitro pre-clinical study
Authors
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May advance organoid-based disease modeling; leaves open in vivo and clinical translation.
Does the inclusion of vascular cells improve the maturation and contractile force of human cardiac organoids?
The inclusion of vascular cells in human cardiac organoids significantly enhances their structural maturation, contractile force, and utility for modeling inflammatory diastolic dysfunction.
Voges et al. (2023) studied Cardiac organoid models. Vascular cells was evaluated on Organoid maturation and contractile force. Vascular cells within human cardiac organoids enhance maturation and contractile force via endothelial-derived LAMA5 and paracrine PDGFRβ signaling, improving their utility in disease modeling.
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