Key result
Type 2 diabetes was associated with significant rest-activity rhythm dysfunction compared to healthy controls, characterized by lower interdaily stability, higher intradaily variability, and lower rhythm amplitude.
Why the study?
Does type 2 diabetes mellitus alter rest-activity rhythm compared to healthy controls?
Cross-Sectional (n=42)
No
Does type 2 diabetes mellitus alter rest-activity rhythm compared to healthy controls?
Type 2 diabetes is associated with dysfunction in rest-activity rhythm, characterized by less consistency, higher fragmentation, and lower amplitude.
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T2DM-linked rhythm disruption is hypothesis-generating; prospective trials needed before clinical adoption or causal inference.
The purpose of this study was to analyze the rest-activity rhythm of type 2 diabetics mellitus (T2DM) and compare it to healthy controls using the nonparametric analytic approach. Twenty-one diabetics and 21 healthy subjects matched for gender and age were recruited to participate in the study. Data were analyzed using the Independent t-test, Mann-Whitney U test, and Spearmans correlation. T2DM subjects demonstrate lower interdaily stability (IS) (p=.03), higher intradaily variability (p=.046) and lower rhythm amplitude (p=.02) when compared to healthy controls. Also, there was a positive correlation between IS and most active 10 hr (M10) in the average of 24 hours pattern (r =.44; p=.046) in the diabetes group and a negative correlation between IV and M10 in the healthy group (r =-.57; p=.007). These data together suggest that T2DM exhibits a dysfunction in the rest-activity rhythm due to alterations in the circadian function as well as in the homeostatic capacity to maintain sleep; mainly characterized by less consistency across days of the daily circadian signal, higher rhythm fragmentation and lower rhythm amplitude. Future approaches may be developed considering the influence of circadian glucose variations throughout the day on the coupling of the rest-activity rhythm to zeitgeber and rhythm fragmentation.
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Cavalcanti-Ferreira et al. (2018) conducted a cross-sectional in Type 2 diabetes mellitus (n=42). Type 2 diabetes vs. Healthy controls was evaluated on Interdaily stability (IS) (Cohen's d 0.54, p=0.03). Type 2 diabetes was associated with significant rest-activity rhythm dysfunction compared to healthy controls, characterized by lower interdaily stability, higher intradaily variability, and lower rhythm amplitude.
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