Key result
Women develop obstructive coronary heart disease and heart failure 10 years later than men, highlighting the need for balanced inclusion and sex-specific reporting in cardiology clinical trials.
Design
Review
Authors
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Sex differences in disease onset merit consideration in trial design; leaves open impact of balanced inclusion on outcome generalizability.
This review highlights the historical underrepresentation of women in cardiology trials and calls for improved trial methodologies, including adaptive designs and sex-specific reporting, to better understand cardiovascular interventions in both sexes.
Clayton et al. (2018) conducted a review in Heart disease. Women develop obstructive coronary heart disease and heart failure 10 years later than men, highlighting the need for balanced inclusion and sex-specific reporting in cardiology clinical trials.
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