What is the clinical evidence from this study?

Study design: Other. Population: Cardiac aging and frailty. Intervention: Frailty (Frailty Index) vs. Chronological age / Fit status. Primary outcome: Cardiac hypertrophy and contractile function (LVDP) (r = 0.67-0.55 (hypertrophy); r = -0.51 (LVDP), p=<0.0003).

What question did this study set out to answer?

To evaluate how frailty, measured as deficit accumulation, impacts age-dependent ventricular remodelling and contractile dysfunction alongside chronological age.

May 14, 2017The Journal of PhysiologyOpen Access

The impact of age and frailty on ventricular structure and function in C57BL/6J mice

Q: What are the key findings of this study?

In naturally aging mice, frailty index scores correlated significantly with cardiac hypertrophy (r=0.67-0.55, P<0.0003) and declines in left ventricular developed pressure (r=-0.51, P=0.0007).

Q: What question did this study set out to answer?

To evaluate how frailty, measured as deficit accumulation, impacts age-dependent ventricular remodelling and contractile dysfunction alongside chronological age.

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Key result

In naturally aging mice, frailty index scores correlated significantly with cardiac hypertrophy (r=0.67-0.55, P<0.0003) and declines in left ventricular developed pressure (r=-0.51, P=0.0007).

Population

Adult (≈7 months) and aged (≈27 months) C57BL/6J mice

Comparison

Frailty and chronological aging vs Adult/fit mice vs aged/frail mice

Design

Preclinical

Authors

HFHirad Feridooni AKAlice E. Kane OAOmar Ayaz

Discussion

Member takes

Overview

Frailty associates with graded cardiac changes in aging mice; hypothesis-generating, no human practice implications.

Key Points

To evaluate how frailty, measured as deficit accumulation, impacts age-dependent ventricular remodelling and contractile dysfunction alongside chronological age.
Quantified deficit accumulation using a validated mouse frailty index (FI) tool in adult (≈7 months) and aged (≈27 months) C57BL/6J mice.
Evaluated intact left ventricular hypertrophy and contractile hemodynamics using ex vivo Langendorff-perfused hearts.
Isolated ventricular myocytes to measure cell surface area, unloaded cell shortening, Ca2+ currents, Ca2+ transients, and Cav1.2 protein expression.
Cardiac hypertrophy was graded by FI score (r = 0.55–0.67, P < 0.0003), and isolated ventricular myocyte area correlated positively with frailty (r = 0.34, P = 0.03).
Left ventricular developed pressure (r = -0.51, P = 0.0007), rate of pressure development (+dP/dt: r = -0.48, P = 0.002), and rate of pressure decay (-dP/dt: r = -0.56, P = 0.0002) declined progressively as frailty increased.
Cardiomyocyte contractile dysfunction was graded by smaller Ca2+ transients, reduced Ca2+ currents (r = -0.40, P = 0.008), lower excitation-contraction gain (r = -0.37, P = 0.02), and decreased Cav1.2 protein expression (r = -0.68, P = 0.003).

Structured PICO

Population

Adult (≈7 months) and aged (≈27 months) C57BL/6J mice

Intervention

Frailty (quantified as deficit accumulation using a validated frailty index tool) and chronological aging

Comparator

Adult/fit mice vs aged/frail mice

Outcome

Cardiac hypertrophy and contractile function (LVDP, +dP/dt, -dP/dt) in Langendorff-perfused hearts, and cellular correlates (Ca2+ transients, Ca2+ currents) in ventricular myocytessurrogate

Main Result

Effect estimate: r = 0.67-0.55 (hypertrophy); r = -0.51 (LVDP)

p-value: p=<0.0003

In naturally aging mice, cardiac hypertrophy and contractile dysfunction are graded by overall health (frailty), suggesting frailty helps explain heterogeneity in cardiac aging.

Cite This Study

Feridooni et al. (2017) studied Cardiac aging and frailty. Frailty (Frailty Index) vs. Chronological age / Fit status was evaluated on Cardiac hypertrophy and contractile function (LVDP) (r = 0.67-0.55 (hypertrophy); r = -0.51 (LVDP), p=<0.0003). In naturally aging mice, frailty index scores correlated significantly with cardiac hypertrophy (r=0.67-0.55, P<0.0003) and declines in left ventricular developed pressure (r=-0.51, P=0.0007).

synapsesocial.com/papers/6a122405ea48cb855a3447ae https://doi.org/10.1113/jp274134

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May 14, 2017The Journal of PhysiologyOpen Access

The impact of age and frailty on ventricular structure and function in C57BL/6J mice

View Full Paper

Ask AI

Bookmark

Key result

In naturally aging mice, frailty index scores correlated significantly with cardiac hypertrophy (r=0.67-0.55, P<0.0003) and declines in left ventricular developed pressure (r=-0.51, P=0.0007).

Population

Adult (≈7 months) and aged (≈27 months) C57BL/6J mice

Comparison

Frailty and chronological aging vs Adult/fit mice vs aged/frail mice

Design

Preclinical

Authors

HFHirad Feridooni AKAlice E. Kane OAOmar Ayaz

Discussion

Member takes

Overview

Frailty associates with graded cardiac changes in aging mice; hypothesis-generating, no human practice implications.

Key Points

To evaluate how frailty, measured as deficit accumulation, impacts age-dependent ventricular remodelling and contractile dysfunction alongside chronological age.
Quantified deficit accumulation using a validated mouse frailty index (FI) tool in adult (≈7 months) and aged (≈27 months) C57BL/6J mice.
Evaluated intact left ventricular hypertrophy and contractile hemodynamics using ex vivo Langendorff-perfused hearts.
Isolated ventricular myocytes to measure cell surface area, unloaded cell shortening, Ca2+ currents, Ca2+ transients, and Cav1.2 protein expression.
Cardiac hypertrophy was graded by FI score (r = 0.55–0.67, P < 0.0003), and isolated ventricular myocyte area correlated positively with frailty (r = 0.34, P = 0.03).
Left ventricular developed pressure (r = -0.51, P = 0.0007), rate of pressure development (+dP/dt: r = -0.48, P = 0.002), and rate of pressure decay (-dP/dt: r = -0.56, P = 0.0002) declined progressively as frailty increased.
Cardiomyocyte contractile dysfunction was graded by smaller Ca2+ transients, reduced Ca2+ currents (r = -0.40, P = 0.008), lower excitation-contraction gain (r = -0.37, P = 0.02), and decreased Cav1.2 protein expression (r = -0.68, P = 0.003).

Structured PICO

Population

Adult (≈7 months) and aged (≈27 months) C57BL/6J mice

Intervention

Frailty (quantified as deficit accumulation using a validated frailty index tool) and chronological aging

Comparator

Adult/fit mice vs aged/frail mice

Outcome

Cardiac hypertrophy and contractile function (LVDP, +dP/dt, -dP/dt) in Langendorff-perfused hearts, and cellular correlates (Ca2+ transients, Ca2+ currents) in ventricular myocytessurrogate

Main Result

Effect estimate: r = 0.67-0.55 (hypertrophy); r = -0.51 (LVDP)

p-value: p=<0.0003

In naturally aging mice, cardiac hypertrophy and contractile dysfunction are graded by overall health (frailty), suggesting frailty helps explain heterogeneity in cardiac aging.

Cite This Study

synapsesocial.com/papers/6a122405ea48cb855a3447ae https://doi.org/10.1113/jp274134

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