Why the study?
Does aging affect cardiac excitation-contraction coupling and contractile function?
Population
Human and animal hearts/myocytes
Comparison
Aging vs Young adult hearts/myocytes
Design
Review
Authors
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Age-related EC coupling changes may limit contractile reserve under stress; leaves open whether targeting Ca2+ proteins preserves function in older adults.
Does aging affect cardiac excitation-contraction coupling and contractile function?
This review highlights that age-related declines in cardiac contractile reserve originate from cellular alterations in excitation-contraction coupling and calcium homeostasis.
Fares et al. (2009) studied this question.
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