Key result
Ageing in animal models was associated with reduced cardiac functional capacity driven by changes in the myocardial Ca2+ transport system.
Authors
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Animal model data on Ca2+ transport in ageing warrant human validation; leaves open any clinical translation or therapeutic targeting.
Frolkis et al. (2009) studied Ageing heart. Ageing was evaluated on Myocardial Ca2+ transport system and contractile function. Ageing in animal models was associated with reduced cardiac functional capacity driven by changes in the myocardial Ca2+ transport system.
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