Restriction of coronary flow by 70% produced significant changes in the Ca2+ transport system and decreased resistance of contractile function, with effects being more marked in old versus adult rats.
Does age affect the resistance of cardiac function and Ca2+ transport to ischemia and reperfusion in isolated rat hearts?
Ischemia and reperfusion cause more severe disturbances in cardiac function and Ca2+ transport in older rat hearts compared to adult ones.
Experiments on isolated hearts from adult and old rats have proved an age-dependent decrease in the resistance of contractile function and cardiac rhythm to ischemia and reperfusion. The restriction of coronary flow by 70% produced significant changes in various links of the Ca2+ transport system (an increase in sarcolemmal permeability for Ca2+ and a decrease in Ca(2+)-accumulating capacity of sarcoplasmic reticulum included). These changes, more marked in old animals, seemed to play an important role in the mechanisms of disturbances in cardiac function following coronary insufficiency.
Frolkis et al. (Wed,) conducted a other in Ischemia and reperfusion. Restriction of coronary flow by 70% vs. Adult rats (compared to old rats) was evaluated on Contractile function, cardiac rhythm, and Ca2+ transport system changes. Restriction of coronary flow by 70% produced significant changes in the Ca2+ transport system and decreased resistance of contractile function, with effects being more marked in old versus adult rats.
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