Why the study?
Does low-flow ischemia affect myocardial function and calcium-regulating proteins differently in adult versus senescent rat hearts?
Population
Isolated hearts from 4-month-old (n=34) and 24-month-old (n=31) rats
Comparison
Graded levels of low-flow ischemia for 180 min vs 100% initial coronary flow (100% CF) for 180 min
Design
Preclinical
Follow-up
180 min
Authors
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Senescent rat hearts show greater vulnerability to low-flow ischemia; hypothesis-generating for age-specific mechanisms in humans.
Does low-flow ischemia affect myocardial function and calcium-regulating proteins differently in adult versus senescent rat hearts?
Senescent rat hearts show higher vulnerability to low-flow ischemia, with greater impairment of myocardial function and earlier increases in mRNAs for calcium-handling proteins compared to adult hearts, without protein loss.
Patrick Assayag (1998) studied this question.
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