Population
Male Sprague Dawley rat hearts and primary cultures of neonatal rat myocytes
Comparison
Ischaemia or chronic low external pH vs Control perfusion or control conditions for…
Design
Preclinical
Follow-up
3 hours
Authors
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May inform ischemic myocardial remodeling mechanisms; leaves open clinical relevance pending human studies.
Low flow ischaemia and chronic acidosis upregulate the Na+/H+ exchanger in mammalian myocardium, though severe ischaemia blunts this response.
Dyck et al. (1995) studied this question.
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