Key result
The Na+-H+ exchange mediates tissue injury during ischemia and reperfusion, and its inhibition shows protective effects in experimental models, leading to clinical evaluation in coronary artery disease.
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Supports NHE inhibition in experimental ischemia-reperfusion; leaves open clinical efficacy in CAD.
The Na+-H+ exchanger, particularly the NHE1 isoform, plays a critical role in myocardial ischemia-reperfusion injury and postinfarction remodeling, making it a potential therapeutic target.
Karmazyn et al. (1999) conducted a review in Ischemia and reperfusion injury, coronary artery disease, heart failure. Na+-H+ exchange (NHE) inhibitors was evaluated. The Na+-H+ exchange mediates tissue injury during ischemia and reperfusion, and its inhibition shows protective effects in experimental models, leading to clinical evaluation in coronary artery disease.
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