Key result
Aging in male Fischer 344 rats was associated with a 43% decrease in maximal left ventricular coronary blood flow and increased minimal coronary vascular resistance at 12 and 20 months.
Why the study?
Does aging alter coronary blood flow and vascular reserve in male Fischer 344 rats?
Population
Conscious, unrestrained male Fischer 344 rats at 4, 12, and 20 months of age
Comparison
Aging (evaluation at 12 and 20 months of age) vs Younger age (4 months of age)
Design
Preclinical
Authors
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May increase ischemic vulnerability in aging rats; leaves open translation to human coronary microvascular aging.
Does aging alter coronary blood flow and vascular reserve in male Fischer 344 rats?
Aging in a rat model is associated with decreased maximal coronary blood flow and increased vascular resistance, mimicking changes seen in pressure overload hypertrophy and potentially increasing vulnerability to ischemia.
Hachamovitch et al. (1989) studied Aging. Aging vs. 4 months of age was evaluated on Maximal coronary blood flow and minimal coronary vascular resistance. Aging in male Fischer 344 rats was associated with a 43% decrease in maximal left ventricular coronary blood flow and increased minimal coronary vascular resistance at 12 and 20 months.
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