What question did this study set out to answer?

To evaluate how aging influences myocardial functional capacity and left ventricular structural remodeling across the rodent lifespan.

October 1, 1990AJP Heart and Circulatory Physiology

Severe myocardial dysfunction induced by ventricular remodeling in aging rat hearts

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Population

Male Fischer 344 rats at 4, 12, 20, and 29 months of age

Comparison

Aging (up to 29 months) vs Younger age intervals (4, 12, and 20 months)

Design

Preclinical

Follow-up

up to 29 months of age

Authors

JCJ. M. CapassoUniversity of Parma TPThomas PalackalNew York State Office for People With Developmental Disabilities GOG OlivettiHeart Failure & Transplant

Discussion

Member takes

Implication

Rat aging model links remodeling failure to HF; leaves open relevance to human age-related cardiomyopathy.

Key Points

To evaluate how aging influences myocardial functional capacity and left ventricular structural remodeling across the rodent lifespan.
Assessed left ventricular hemodynamics and morphology in male Fischer 344 rats at 4, 12, 20, and 29 months of age using quantitative physiology and morphometric analysis.
Quantified cardiac chamber volumes, wall thickness, myocardial fibrotic area fraction, ventricular pressures, and functional output metrics.
In vivo cardiac pump performance remained stable through 20 months, but 29-month-old rats exhibited elevated end-diastolic pressure along with marked declines in stroke volume, ejection fraction, cardiac output, and rates of pressure rise and decay.
Ventricular end-diastolic and end-systolic volumes steadily expanded alongside significant increases in the number and cross-sectional area of myocardial fibrotic lesions, with peak structural changes between 20 and 29 months.
Ventricular wall stress throughout the cardiac cycle increased by 64% from 4 to 12 months, 44% from 12 to 20 months, and 50% from 20 to 29 months, showing failure of remodeling to normalize mechanical load.

Structured PICO

Population

Male Fischer 344 rats at 4, 12, 20, and 29 months of age

Intervention

Aging (up to 29 months)

Comparator

Younger age intervals (4, 12, and 20 months)

Outcome

Hemodynamic performance and structural characteristics of the left ventricle (including cardiac pump function, chamber size, wall thickness, and fibrosis)surrogate

In a rat model, aging is associated with progressive ventricular remodeling, increased wall stress, and eventual onset of heart failure.

Cite This Study

Capasso et al. (1990) studied this question.

synapsesocial.com/papers/6a7fa77ea9500df4273e87c1 https://doi.org/10.1152/ajpheart.1990.259.4.h1086

Topics

Cardiomyopathy

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October 1, 1990AJP Heart and Circulatory Physiology

Severe myocardial dysfunction induced by ventricular remodeling in aging rat hearts

View Full Paper

Ask AI

Bookmark

Population

Male Fischer 344 rats at 4, 12, 20, and 29 months of age

Comparison

Aging (up to 29 months) vs Younger age intervals (4, 12, and 20 months)

Design

Preclinical

Follow-up

up to 29 months of age

Authors

JCJ. M. CapassoUniversity of Parma TPThomas PalackalNew York State Office for People With Developmental Disabilities GOG OlivettiHeart Failure & Transplant

Discussion

Member takes

Implication

Rat aging model links remodeling failure to HF; leaves open relevance to human age-related cardiomyopathy.

Key Points

To evaluate how aging influences myocardial functional capacity and left ventricular structural remodeling across the rodent lifespan.
Assessed left ventricular hemodynamics and morphology in male Fischer 344 rats at 4, 12, 20, and 29 months of age using quantitative physiology and morphometric analysis.
Quantified cardiac chamber volumes, wall thickness, myocardial fibrotic area fraction, ventricular pressures, and functional output metrics.
In vivo cardiac pump performance remained stable through 20 months, but 29-month-old rats exhibited elevated end-diastolic pressure along with marked declines in stroke volume, ejection fraction, cardiac output, and rates of pressure rise and decay.
Ventricular end-diastolic and end-systolic volumes steadily expanded alongside significant increases in the number and cross-sectional area of myocardial fibrotic lesions, with peak structural changes between 20 and 29 months.
Ventricular wall stress throughout the cardiac cycle increased by 64% from 4 to 12 months, 44% from 12 to 20 months, and 50% from 20 to 29 months, showing failure of remodeling to normalize mechanical load.

Structured PICO

Population

Male Fischer 344 rats at 4, 12, 20, and 29 months of age

Intervention

Aging (up to 29 months)

Comparator

Younger age intervals (4, 12, and 20 months)

Outcome

Hemodynamic performance and structural characteristics of the left ventricle (including cardiac pump function, chamber size, wall thickness, and fibrosis)surrogate

In a rat model, aging is associated with progressive ventricular remodeling, increased wall stress, and eventual onset of heart failure.

Cite This Study

Capasso et al. (1990) studied this question.

synapsesocial.com/papers/6a7fa77ea9500df4273e87c1 https://doi.org/10.1152/ajpheart.1990.259.4.h1086

Also Consider

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Topics

Cardiomyopathy

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