June 1, 1992AJP Heart and Circulatory Physiology

Cellular mechanisms of ventricular failure: myocyte kinetics and geometry with age

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Population

Fischer 344 rats at 4, 12, 20, and 29 months of age

Comparison

Aging (evaluation at 12, 20, and 29 months of age) vs 4-month-old animals

Design

Preclinical

Authors

JCJ. M. CapassoUniversity of Parma DFDavid FitzpatrickBoston University PAPiero AnversaUniversità Cattolica del Sacro Cuore

Discussion

Member takes

Implication

Does not alter clinical HF management; extends preclinical evidence on age-related myocyte remodeling but leaves translation open.

Structured PICO

Population

Fischer 344 rats at 4, 12, 20, and 29 months of age

Intervention

Aging (evaluation at 12, 20, and 29 months of age)

Comparator

4-month-old animals

Outcome

Myocyte kinetics and geometry (length, width, shape, shortening velocity, relengthening velocity, contraction duration)surrogate

Age-related alterations in myocyte geometry and depressed contractile performance are major contributors to the transition from normal cardiac dynamics to left ventricular dysfunction and failure.

Cite This Study

Capasso et al. (1992) studied this question.

synapsesocial.com/papers/6a908f2fc7b7d4543f89f987 https://doi.org/10.1152/ajpheart.1992.262.6.h1770

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June 1, 1992AJP Heart and Circulatory Physiology

Cellular mechanisms of ventricular failure: myocyte kinetics and geometry with age

View Full Paper

Ask AI

Bookmark

Population

Fischer 344 rats at 4, 12, 20, and 29 months of age

Comparison

Aging (evaluation at 12, 20, and 29 months of age) vs 4-month-old animals

Design

Preclinical

Authors

JCJ. M. CapassoUniversity of Parma DFDavid FitzpatrickBoston University PAPiero AnversaUniversità Cattolica del Sacro Cuore

Discussion

Member takes

Implication

Does not alter clinical HF management; extends preclinical evidence on age-related myocyte remodeling but leaves translation open.

Structured PICO

Population

Fischer 344 rats at 4, 12, 20, and 29 months of age

Intervention

Aging (evaluation at 12, 20, and 29 months of age)

Comparator

4-month-old animals

Outcome

Myocyte kinetics and geometry (length, width, shape, shortening velocity, relengthening velocity, contraction duration)surrogate

Age-related alterations in myocyte geometry and depressed contractile performance are major contributors to the transition from normal cardiac dynamics to left ventricular dysfunction and failure.

Cite This Study

Capasso et al. (1992) studied this question.

synapsesocial.com/papers/6a908f2fc7b7d4543f89f987 https://doi.org/10.1152/ajpheart.1992.262.6.h1770

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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