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March 1, 1990Coronary Artery Disease

Differences in the temporal effects of aging on the structure and function of rat myocardium

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Population

Rats at 3, 11, and 19 months of age

Comparison

Aging (evaluation at 3, 11, and 19 months of age) vs Comparison between age groups and between left…

Design

Preclinical

Authors

GOG OlivettiHeart Failure & TransplantJCJ. M. CapassoUniversity of ParmaESEdmund H. SonnenblickUniversity of Parma

Discussion

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Implication

These rat microvascular changes may contribute to human myocardial aging; leaves open clinical relevance and need for human validation.

Structured PICO

P
Population
Rats at 3, 11, and 19 months of age
I
Intervention
Aging (evaluation at 3, 11, and 19 months of age)
C
Comparator
Comparison between age groups (3, 11, and 19 months) and between left and right ventricles
O
Outcome
Mechanical characteristics of left and right ventricular myocardium, quantitative analysis of the capillary network, and subcellular components of myocytessurrogate

Aging in rats leads to structural changes in the myocardial capillary microvasculature and increased collagen, with left ventricular changes preceding right ventricular changes, while largely preserving mechanical function and energy-producing subcellular structures.

Cite This Study

Olivetti et al. (1990) studied this question.

synapsesocial.com/papers/6a86c8adf87adc0a02ca0db5https://doi.org/10.1097/00019501-199003000-00013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of age on mechanical and structural properties of myocardium of Fischer 344 rats1989 · 50 citations
  2. 2Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.1990 · 407 citations
  3. 3Effects of age on mechanical and electrical performance of rat myocardium1983 · 140 citations
  4. 4Cellular mechanisms of ventricular failure: myocyte kinetics and geometry with age1992 · 48 citations
  5. 5Severe myocardial dysfunction induced by ventricular remodeling in aging rat hearts1990 · 103 citations