Population
Left ventricular papillary muscle preparations isolated from 6-, 15-, and 27- to 32-month-old Sprague-Dawley…
Comparison
Aging (27- to 32-month-old rats) vs Young (6-month-old) and adult (15-month-old) rats
Design
Preclinical
Authors
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Aging reduces rat cardiac work output without efficiency loss; hypothesis-generating for human age-related decline and requires clinical validation.
Aging in rats leads to a pronounced decline in cardiac muscle stress development and shortening ability, reducing work output, while mechanical and contractile efficiency remain unchanged.
Helen Kiriazis (2000) studied this question.
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