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October 1, 1996Hypertension

Myocyte Remodeling During the Progression to Failure in Rats With Hypertension

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Authors

AGA. Martin GerdesPhiladelphia College of Osteopathic MedicineTOTatsuyuki OnoderaJikei University School of MedicineXWXuejun WangQingdao University

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Implication

Defective transverse growth in hypertensive rat myocytes may drive remodeling; leaves open whether shape modulation offers therapeutic targets in human hypertension.

Key Points

  • The aim is to understand the changes in cardiac myocyte shape during the progression of heart failure due to hypertension.
  • Examined left and right ventricular myocytes from spontaneously hypertensive/heart failure rats.
  • Analyzed myocyte volume, length, and shape changes over a period of 12 to 24 months.
  • Compared findings with previous human disease data to validate the animal model.
  • Left ventricular myocyte volume increased by 27%, primarily due to a 29% increase in length.
  • Right ventricular myocyte volume increased by 72%, with proportional growth (23% length, 18% width).
  • Left ventricular myocyte transverse growth was defective, linked to cell lengthening without diameter change.

Cite This Study

Gerdes et al. (1996) studied this question.

synapsesocial.com/papers/6a6f5a778031ec7bb1dbb522https://doi.org/10.1161/01.hyp.28.4.609

Topics

Heart failureHypertension managementHFrEF treatment
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