Key result
Hypertensive ventricular hypertrophy was associated with a 112% and 84% increase in left and right myocyte cell volume, alongside a 30% and 16% loss in myocytes, respectively.
Why the study?
Does hypertensive cardiomyopathy cause changes in the numbers and size of ventricular myocytes compared to normal hearts?
Case-Control (n=16)
Does hypertensive cardiomyopathy cause changes in the numbers and size of ventricular myocytes compared to normal hearts?
In compensated hypertensive cardiomyopathy, ventricular hypertrophy is driven by myocyte cellular hypertrophy, accompanied by significant myocyte loss and replacement fibrosis.
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Supports the concept of replacement fibrosis driving compensated hypertensive cardiomyopathy, leaving open whether early BP control prevents this specific.
Olivetti et al. (1994) conducted a case-control in Ventricular hypertrophy (n=16). Hypertensive ventricular hypertrophy vs. Normal hearts was evaluated on Changes in the numbers and size of ventricular myocytes. Hypertensive ventricular hypertrophy was associated with a 112% and 84% increase in left and right myocyte cell volume, alongside a 30% and 16% loss in myocytes, respectively.
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