Why the study?
Does the total number of myocardial cells increase in left ventricular hypertrophy?
Does the total number of myocardial cells increase in left ventricular hypertrophy?
Cardiac hypertrophy is induced by geometrically similar enlargement of individual myocardial cells rather than an increase in cell number.
Cell number stability in LV hypertrophy questions hyperplasia-targeted approaches; leaves open in vivo confirmation.
The total number of myocardial cells of the left ventricle of normal and hypertrophied hearts was histometrically evaluated in autopsy cases. In the postnatal life it was kept constant both in physiological and pathological growth of the heart. It was concluded that cardiac hypertrophy was induced by geometrically similar enlargement of individual myocardial cells. The role of amitoses of the myocardial nuclei in numerical increase of the heart muscle cells was rather doubtful.
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Arai et al. (1972) studied this question.
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