December 16, 2004Cardiovascular ResearchOpen Access

Aging decreases vasoconstrictor responses of coronary resistance arterioles through endothelium-dependent mechanisms

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Population

Isolated coronary arterioles from myocardium of young (4 months) and old (24 months) Fischer 344 rats

Comparison

Aging and exposure to vasoconstrictors with or… vs Young (4 months) Fischer 344 rats

Design

Preclinical

Authors

RSRobert D. ShipleyBoston Scientific (United States)JMJudy M. Muller‐DelpFlorida State University

Discussion

Member takes

Implication

Should not yet alter clinical management of coronary disease in aging; leaves open human translation of ETB/endothelium mechanisms.

Structured PICO

Population

Isolated coronary arterioles from myocardium of young (4 months) and old (24 months) Fischer 344 rats

Intervention

Aging (24 months vs 4 months) and exposure to vasoconstrictors (endothelin, KCl, pressure) with or without endothelium removal, L-NAME, or ETB receptor blockade

Comparator

Young (4 months) Fischer 344 rats

Outcome

Vasoconstrictor responsiveness to endothelin, potassium chloride, and pressure-induced myogenic responsessurrogate

Aging decreases vasoconstrictor responses of coronary resistance arterioles through enhanced endothelium-dependent mechanisms, likely due to increased basal release of nitric oxide.

Cite This Study

Shipley et al. (2004) studied this question.

synapsesocial.com/papers/6a6f9aaaac440176ef284442 https://doi.org/10.1016/j.cardiores.2004.11.005

View Full Paper

Ask AI

Bookmark

Aging decreases vasoconstrictor responses of coronary resistance arterioles through endothelium-dependent mechanisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Aging decreases vasoconstrictor responses of coronary resistance arterioles through endothelium-dependent mechanisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider