Key result
Aging significantly reduced endothelium-dependent vasodilation induced by flow in rat skeletal muscle arterioles, whereas smooth muscle vasodilatory responses remained intact.
Why the study?
Does aging impair endothelium-dependent vasodilation in rat skeletal muscle arterioles?
Does aging impair endothelium-dependent vasodilation in rat skeletal muscle arterioles?
Aging specifically impairs endothelium-dependent vasodilation in skeletal muscle resistance arterioles without affecting smooth muscle vasodilatory responses.
Authors
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May underlie age-related skeletal muscle hypoperfusion; leaves open human relevance and therapeutic targeting.
Muller‐Delp et al. (2002) studied Aging. Aging (24 months) vs. Young (4 months) was evaluated on Vasodilatory responses to ACh, adenosine, sodium nitroprusside, and flow. Aging significantly reduced endothelium-dependent vasodilation induced by flow in rat skeletal muscle arterioles, whereas smooth muscle vasodilatory responses remained intact.
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