Key result
Aging significantly reduced endothelium-dependent vasodilation induced by flow in rat skeletal muscle arterioles, whereas smooth muscle vasodilatory responses remained intact.
Why the study?
Does aging impair endothelium-dependent vasodilation in rat skeletal muscle arterioles?
Population
First-order arterioles isolated from gastrocnemius and soleus muscles of young and aged Fischer-144 rats
Comparison
Aging (24 months old) vs Young (4 months old)
Design
Preclinical
Authors
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May underlie age-related skeletal muscle hypoperfusion; leaves open human relevance and therapeutic targeting.
Does aging impair endothelium-dependent vasodilation in rat skeletal muscle arterioles?
Aging specifically impairs endothelium-dependent vasodilation in skeletal muscle resistance arterioles without affecting smooth muscle vasodilatory responses.
Muller‐Delp et al. (2002) studied Aging. Aging (24 months) vs. Young (4 months) was evaluated on Vasodilatory responses to ACh, adenosine, sodium nitroprusside, and flow. Aging significantly reduced endothelium-dependent vasodilation induced by flow in rat skeletal muscle arterioles, whereas smooth muscle vasodilatory responses remained intact.
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