Why the study?
Does endurance exercise training reduce endothelin-1 vasoconstrictor responses in skeletal muscle arterioles of old rats?
Population
51 male Fischer 344 rats, including young sedentary, old sedentary, young trained, and old trained.
Comparison
Endurance exercise training vs Sedentary control (no exercise training)
Design
Preclinical
Follow-up
12 weeks
Authors
Loading...
Endurance exercise does not reverse age-related ET-1 hyperreactivity in rat muscle arterioles; leaves open translation to human vascular aging and alternative interventions.
Does endurance exercise training reduce endothelin-1 vasoconstrictor responses in skeletal muscle arterioles of old rats?
Aging augments ET-1-mediated vasoconstriction in fast-twitch skeletal muscle arterioles via ETA receptors, but this age-related vascular dysfunction is not reversed by 12 weeks of endurance exercise training.
Donato et al. (2004) studied this question.