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November 3, 2006The Journal of PhysiologyOpen Access

Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles

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Why the study?

Does chronic treadmill exercise training alter arteriolar adrenergic vasoreactivity in young and old male Fischer 344 rats?

Population

Young and old male Fischer 344 rats

Comparison

Chronic treadmill exercise training vs Sedentary control

Design

Preclinical

Key result

Exercise training in old rats attenuated age-augmented alpha-adrenergic vasoconstriction in skeletal muscle arterioles through an endothelial alpha-receptor-NOS-signalling pathway.

Authors

ADAnthony J. DonatoLLLisa A. LesniewskiMDMichael D. Delp

Discussion

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Overview

Hypothesis-generating for exercise effects on aged vascular adrenergic signaling; requires human studies before clinical translation.

Structured PICO

Does chronic treadmill exercise training alter arteriolar adrenergic vasoreactivity in young and old male Fischer 344 rats?

P
Population
Young and old male Fischer 344 rats studied to examine the effects of ageing and exercise training on arteriolar adrenergic vasoreactivity.
I
Intervention
Chronic treadmill exercise training
C
Comparator
Sedentary control (young sedentary and old sedentary groups)
O
Outcome
Arteriolar adrenergic vasoreactivity (responses to noradrenaline, isoproterenol, and forskolin in isolated soleus and gastrocnemius muscle arterioles)surrogate

Exercise training attenuates age-related increases in alpha-adrenergic vasoconstriction in skeletal muscle arterioles, highlighting a potential mechanism for its cardiovascular benefits.

Cite This Study

Donato et al. (2006) studied Ageing. Exercise training vs. Sedentary was evaluated on Arteriolar adrenergic vasoreactivity (responses to noradrenaline, isoproterenol, and forskolin). Exercise training in old rats attenuated age-augmented alpha-adrenergic vasoconstriction in skeletal muscle arterioles through an endothelial alpha-receptor-NOS-signalling pathway.

synapsesocial.com/papers/6a9cef38a1304504b9599c4ehttps://doi.org/10.1113/jphysiol.2006.120055
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of ageing and exercise training on endothelium‐dependent vasodilatation and structure of rat skeletal muscle arterioles2004 · 208 citations
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