Key result
Exercise training enhanced flow-induced vasodilatation and restored BH4 content and flow-stimulated NO availability in soleus muscle arterioles of old male rats.
Why the study?
Does exercise training improve flow-induced vasodilatation and eNOS coupling in soleus muscle arterioles of young and old rats?
Population
Young (3 months) and old (22 months) male rats
Comparison
Exercise training for 10 weeks vs Sedentary (SED) for 10 weeks
Design
Preclinical
Follow-up
10 weeks
Authors
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Highlights potential exercise benefits for age-related vascular decline; leaves open human translation from this animal model.
Does exercise training improve flow-induced vasodilatation and eNOS coupling in soleus muscle arterioles of young and old rats?
Exercise training restores flow-induced vasodilatation and NO availability in aged skeletal muscle arterioles, highlighting the role of eNOS uncoupling in age-related vascular decline.
Sindler et al. (2009) studied Ageing. Exercise training vs. Sedentary was evaluated on Flow-induced vasodilatation and levels of NO and O(2)(-). Exercise training enhanced flow-induced vasodilatation and restored BH4 content and flow-stimulated NO availability in soleus muscle arterioles of old male rats.
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