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March 20, 2009Journal of Applied PhysiologyOpen Access

Exercise training reverses age-related decrements in endothelium-dependent dilation in skeletal muscle feed arteries

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Why the study?

Does exercise training improve age-related decrements in endothelium-dependent dilation in skeletal muscle feed arteries in rats?

Population

Young (2 mo) and old (22 mo) male Fischer 344 rats

Comparison

Exercise training for 10-12 weeks vs Sedentary control for 10-12 weeks

Design

Preclinical

Follow-up

10-12 weeks

Authors

DTDaniel W. TrottFGFiliz GündüzMLM. Harold Laughlin

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Overview

Exercise training restores NO-dependent dilation in aged rat arteries; leaves open translation to human skeletal muscle vasculature.

Key Points

  • This research aims to investigate how exercise training influences endothelium-dependent dilation in muscle feed arteries of aged rats.
  • Young and old male Fischer 344 rats were divided into four groups: young Sed, young Ex, old Sed, and old Ex, and trained for 10-12 weeks.
  • Soleus muscle feed arteries were examined for endothelium-dependent and independent vasodilator function using ACh and SNP.
  • Various inhibitors like l-NNA and Indo were used to assess the mechanisms behind the exercise-induced improvements in dilation.
  • ACh-induced dilation was significantly reduced in old Sed compared to young Sed SFA, indicating endothelial dysfunction in aged arteries.
  • Exercise training restored ACh-induced dilation in old SFA to levels comparable with both young Sed and young Ex.
  • Increased SOD protein content was observed in old Ex SFA, highlighting the role of antioxidant capacity in improving endothelial function.

Structured PICO

Does exercise training improve age-related decrements in endothelium-dependent dilation in skeletal muscle feed arteries in rats?

P
Population
Young (2 mo) and old (22 mo) male Fischer 344 rats
I
Intervention
Exercise training for 10-12 weeks
C
Comparator
Sedentary control for 10-12 weeks
O
Outcome
Endothelium-dependent (ACh) and endothelium-independent (sodium nitroprusside) vasodilator function in isolated soleus muscle feed arteriessurrogate

Exercise training reverses age-induced endothelial dysfunction in skeletal muscle feed arteries by increasing NO bioavailability and vascular antioxidant capacity.

Cite This Study

Trott et al. (2009) studied this question.

synapsesocial.com/papers/6a1fc955117dfefbb99899a4https://doi.org/10.1152/japplphysiol.91232.2008
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