Why the study?
Does exercise training reverse age-related impairment of myogenic vasoconstriction in skeletal muscle arterioles in male Fischer 344 rats?
Population
Young (4-6 months) and old (22-24 months) male Fischer 344 rats (n=109)
Comparison
Exercise training consisting of treadmill… vs Sedentary control group
Design
Preclinical, randomly assigned to either a sedentary group or exercise-trained…
Follow-up
10-12 weeks
Key result
Exercise training restored myogenic constriction in skeletal muscle arterioles from old rats to levels similar to young sedentary rats and enhanced constriction in young rats.
Authors
Loading...
Should not yet change clinical practice; hypothesis-generating for human translation of exercise effects on microvascular myogenic tone.
Does exercise training reverse age-related impairment of myogenic vasoconstriction in skeletal muscle arterioles in male Fischer 344 rats?
p-value: p=<0.05
Exercise training reverses age-related impairments in skeletal muscle arteriolar myogenic constriction through adaptations in the endothelium and smooth muscle Kv1 channels.
Ghosh et al. (2015) studied Aging-induced impairment of myogenic constriction (n=109). Exercise training vs. Sedentary was evaluated on Myogenic constriction of soleus muscle arterioles (p=<0.05). Exercise training restored myogenic constriction in skeletal muscle arterioles from old rats to levels similar to young sedentary rats and enhanced constriction in young rats.