Population
Mesenteric resistance arteries of 4, 9 and 27 month old Fischer 344 rats
Comparison
Endothelin-1 (10(-14) - 3 x 10(-8) M) vs Different age groups and presence/absence of…
Design
Preclinical
Authors
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Aging alters ET-1 vascular effects in rat arteries; leaves open relevance to human vascular aging and endothelin-targeted therapies.
Aging alters the vascular response to endothelin-1 in rat mesenteric arteries, decreasing direct contractile effects while increasing indirect potentiating effects.
Dohi et al. (1990) studied this question.
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