April 1, 1994British Journal of PharmacologyOpen Access

Reduction of endothelial function with age in the mesenteric arterial bed of the normotensive rat

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Why the study?

Does aging reduce endothelial vasodilator function in the mesenteric arterial bed of normotensive rats?

Population

Male, normotensive, Wistar rats at 2, 12, or 22 months of age

Comparison

Aging (22 months of age) vs Younger rats (2 and 12 months of age)

Design

Preclinical

Authors

JAJeffrey AtkinsonBrock University RTRabelais Tatchum‐TalomUPMC McKeesport CCChristine Capdeville‐AtkinsonCibles thérapeutiques, formulation et expertise préclinique du médicament

Discussion

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Implication

Aging may impair endothelial function in rat resistance vessels; hypothesis-generating and leaves open relevance to human vascular aging.

Structured PICO

Does aging reduce endothelial vasodilator function in the mesenteric arterial bed of normotensive rats?

Population

Male, normotensive, Wistar rats at 2, 12, or 22 months of age

Intervention

Aging (22 months of age)

Comparator

Younger rats (2 and 12 months of age)

Outcome

Endothelial vasodilator function (measured by carbachol-induced release of EDRF and noradrenaline-induced vasoconstriction)surrogate

Aging in normotensive rats leads to a reduction in endothelial vasodilator function in resistance vessels.

Cite This Study

Atkinson et al. (1994) studied this question.

synapsesocial.com/papers/6a83fca642ccde92f8c581f6 https://doi.org/10.1111/j.1476-5381.1994.tb14870.x

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Reduction of endothelial function with age in the mesenteric arterial bed of the normotensive rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reduction of endothelial function with age in the mesenteric arterial bed of the normotensive rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider