Population
Sprague-Dawley rats (young and old)
Comparison
Noradrenaline stimulation vs Young vs. old rats; intact vs. denuded endothelium
Design
Preclinical
Authors
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Endothelium-dependent noradrenaline hypercontractility in aged rat tail arteries is hypothesis-generating; leaves open translation to human vascular aging.
Ageing increases maximal contraction to noradrenaline in rat tail arteries but not aorta, and this effect is dependent on the presence of the endothelium.
Tabernero et al. (1995) studied this question.
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