Key result
Ischemic preconditioning reduces infarct size ~52% in young rats but loses cardioprotection in mature rats.
Absolute Event Rate: 16% vs 33%
p-value: p=<0.05
Aging-related loss of ischemic preconditioning efficacy in rat hearts is associated with dysfunction in pro-survival signaling pathways including Akt, eNOS, and PKCepsilon.
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Aging may abolish preconditioning benefits in mature rat hearts; leaves open whether Akt/eNOS/PKCε pathways can be targeted to restore cardioprotection in older adults.
Griecsová et al. (2015) studied Myocardial ischemia/reperfusion injury. Ischemic preconditioning vs. No preconditioning (control) was evaluated on Size of myocardial infarction as percentage of area at risk (IS/AR) in 3-month-old rats (p=<0.05). Ischemic preconditioning significantly reduced myocardial infarct size from 33% to 16% in 3-month-old rats, but this cardioprotective effect was lost in 6-month-old mature rats.
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