Why the study?
Does PKC-epsilon mediate infarct size reduction with ischemic preconditioning in old rabbits compared to adult rabbits?
Population
Adult and old (approximately 4-yr-old) rabbits
Comparison
Ischemic preconditioning with or without… vs Matched control period followed by 30 min of…
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
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Age alters PKC-epsilon dependence of preconditioning in rabbits; hypothesis-generating for elderly-specific mechanisms and warrants caution in clinical translation.
Does PKC-epsilon mediate infarct size reduction with ischemic preconditioning in old rabbits compared to adult rabbits?
The mechanisms of myocardial ischemic preconditioning are age-related, with PKC-epsilon playing a requisite role in cardioprotection in adult but not old rabbits.
Przyklenk et al. (2003) studied this question.
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