Population
Ventricular cardiomyocytes isolated from young-adult and middle-aged Fischer 344 rats
Comparison
Exposure to 100 nmol/L 4-beta-phorbol… vs Young-adult versus middle-aged cardiomyocytes
Design
Preclinical
Authors
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May underlie reduced ischemic tolerance in aging; leaves open PKC-delta targeting in aged models.
Age-related attenuation of PKC-delta expression and translocation may explain the reduced ischemic tolerance and preconditioning efficacy observed in older hearts.
Takayama et al. (2001) studied this question.
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