Population
Isolated neonatal rat cardiocytes
Comparison
Expression of constitutively active isotypes of… vs Empty vector
Design
Preclinical
Follow-up
6 hours of simulated ischemia
Authors
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PKC-delta may confer ischemia resistance in neonatal models; leaves open translation to adult myocardium or clinical cardioprotection.
Expression of active PKC-delta in neonatal cardiocytes increases resistance to simulated ischemia, potentially via a protective bystander effect.
Zhao et al. (1998) studied this question.
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