Why the study?
Does the number of ischemic preconditioning episodes alter the cardioprotective effect and its dependence on protein kinase C in a rabbit model of myocardial infarction?
Does the number of ischemic preconditioning episodes alter the cardioprotective effect and its dependence on protein kinase C in a rabbit model of myocardial infarction?
Repetitive ischemic preconditioning confers cardioprotection through a partially PKC-independent mechanism, unlike single preconditioning which is highly PKC-dependent.
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Repetitive preconditioning may engage PKC-independent pathways in rabbits; leaves open relevance to human cardioprotection.
Tetsuji Miura (1998) studied this question.
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