Population
Aged (19 months) and young (4 months) male F344 BN rats
Comparison
30 min of myocardial ischemia by ligating the… vs Sham control (young and aged rats)
Design
Preclinical
Follow-up
4 hours of reperfusion
Authors
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Apoptosis may predominate in age-related post-MI/R vulnerability; extends preclinical models but leaves translation to humans open.
In a rat model of myocardial ischemia-reperfusion, aged rats exhibit worse myocardial dysfunction and increased cardiomyocyte apoptosis compared to young rats, despite a blunted inflammatory response.
P. Liu (2002) studied this question.
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