Key result
Old rats exhibit reduced isometric tension, prolonged action potentials, and delayed CaT decay versus young rats.
Population
Right ventricular trabeculae from male Wistar rats
Comparison
Young (1 month) vs old (2.5 years) rats under varying degrees of stretching
Design
Comparative experimental animal study
Authors
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Age-related rat myocardial changes warrant caution against human extrapolation; extends length-dependent contractility models but leaves clinical relevance open.
Aging in rats is associated with altered length-dependent regulation of myocardial contractility, characterized by reduced isometric tension and prolonged calcium transient decay.
Lisin et al. (2025) studied Healthy myocardium during aging. Old age (2.5 years) vs. Young age (1 month) was evaluated on Characteristics of mechanical and electrical activity, and kinetics of intracellular calcium ion concentration (CaT) under varying degrees of stretching. Old rats exhibited lower amplitude and reduced rate of isometric tension development, longer action potential duration, and significantly longer CaT decay time compared to young rats.
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