June 1, 1984AJP Heart and Circulatory Physiology
Excitation-contraction in rat myocardium: alterations with adult aging
Population
Thin right ventricular papillary muscles isolated from senescent and young adult rat hearts
Comparison
Senescence (aging to 24-26 months) vs Young adult (6-8 months) rat hearts
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May influence force development in aged myocardium; hypothesis-generating for human cardiac senescence.
Structured PICO
P
Population
Thin right ventricular papillary muscles isolated from senescent (24-26 months) and young adult (6-8 months) rat hearts
I
Intervention
Senescence (aging to 24-26 months)
C
Comparator
Young adult (6-8 months) rat hearts
O
Outcome
Transmembrane action potential (TAP) and isometric contraction measurements (contractile tension, maximum rate of tension development, contraction duration, resting membrane potential, repolarization times)surrogate
In senescent rat myocardium, prolonged depolarization is associated with prolonged contraction duration and may influence peak force development.
Cite This Study
Wei et al. (1984) studied this question.