Key result
High serum hs-CRP levels (>3 mg/L) in patients with atrial fibrillation were significantly associated with a higher mortality rate (72.31%) compared to average levels (29.41%, p<0.001).
Why the study?
Serum high sensitivity C-reactive protein level and risk category add prognostic information beyond global risk prediction models in patients with atrial fibrillation.
Observational (n=86)
Yes
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia necessitating hospitalization and associated with significant rates of morbidity and mortality. 1 Several haemostatic and inflammatory markers, novel lipid parameters, markers of oxidative stress, and cellular adhesion molecules have been linked to steps in atherogenesis, thrombosis, or cardiovascular disease events like AF. 2 But only Serum high sensitivity C-Reactive Protein (Sr. hs-CRP) level and risk category has been shown to add prognostic information over and above that provided by global risk prediction models by the Framingham Risk Score.
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Natarajan et al. (2019) conducted an observational in Atrial Fibrillation (n=86). High serum hs-CRP risk category (>3 mg/L) vs. Average hs-CRP risk category (1-3 mg/L) was evaluated on Mortality (Expired rate) (p=<0.001). High serum hs-CRP levels (>3 mg/L) in patients with atrial fibrillation were significantly associated with a higher mortality rate (72.31%) compared to average levels (29.41%, p<0.001).
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