High-Sensitivity C-Reactive Protein is a Predictor of Subsequent Atrial High-Rate Episodes in Patients with Pacemakers and Preserved Ejection Fraction

Figures

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  Figure 1. Estimated cumulative atrial high-rate episode (AHRE)-free survival (Kaplan–Meier) analysis between high-sensitivity C-reactive protein (hs-CRP) > 0.525 mg/L and hs-CRP ≤ 0.525 mg/L in (A) all patients, (B) patients without prior atrial fibrillation (AF), and (C) patients without prior AF and congestive heart failure (CHF). The cut-point value was optimized from the receiver operating characteristics (ROC) curves.

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  Figure 2. Receiver operating characteristic (ROC) curves from logistic regression models predicting subsequent atrial high-rate episodes (AHREs) ≥ 6 min. (1) Model (long dotted line) with the variables sick sinus syndrome (SSS), prior atrial fibrillation (AF), and mitral valve (MV) A wave. (2) Model + high-sensitivity C-reactive protein (hs-CRP) level (short dotted line). (3) Model + hs-CRP group (cut-point value 0.525 mg/L, solid line) and discrimination and reclassification accuracy of the risk markers of atrial high-rate episodes. a The model included the clinical parameters, which remained significant predictors of AHREs in the Cox multivariate hazards model; b hs-CRP as a continuous variable was added to the model; c hs-CRP as a dichotomized variable was added to the model. The optimized cut-point value of hs-CRP obtained by receiver operating characteristics was 0.525 mg/L. Abbreviations: AUC, area under the curve; IDI, Integrated discrimination index; NRI, net reclassification index; hs-CRP, high-sensitivity C-reactive protein.