Key result
Higher baseline hs-CRP levels were significantly associated with atrial fibrillation recurrence at 1 month after electrical cardioversion (0.5 mg/dl vs 0.29 mg/dl; p<0.001).
Why the study?
Do baseline high-sensitivity C-reactive protein (hs-CRP) levels predict atrial fibrillation recurrence after electrical cardioversion in patients with persistent AF?
Population
52 patients with persistent atrial fibrillation (AF) lasting >3 months
Design
Cohort
Follow-up
1 month
Authors
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May aid early recurrence risk stratification after cardioversion; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=52)
No
Do baseline high-sensitivity C-reactive protein (hs-CRP) levels predict atrial fibrillation recurrence after electrical cardioversion in patients with persistent AF?
Absolute Event Rate: 0.5% vs 0.29%
p-value: p=<0.001
Elevated baseline hs-CRP predicts AF recurrence after cardioversion, and successful maintenance of sinus rhythm lowers hs-CRP, suggesting inflammation is a consequence rather than a cause of AF.
Kallergis et al. (2007) conducted a cohort in Persistent atrial fibrillation (n=52). Electrical cardioversion vs. Maintenance of sinus rhythm was evaluated on Baseline hs-CRP levels in patients with AF recurrence versus those maintaining sinus rhythm (p=<0.001). Higher baseline hs-CRP levels were significantly associated with atrial fibrillation recurrence at 1 month after electrical cardioversion (0.5 mg/dl vs 0.29 mg/dl; p<0.001).
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