C reactive protein concentration and recurrence of atrial fibrillation after electrical cardioversion
Key result
High CRP concentration was associated with increased atrial fibrillation recurrence after electrical cardioversion compared to lower CRP concentration (HR 2.0; 95% CI 1.2-3.2; p=0.007).
Why the study?
Does a high C reactive protein concentration predict recurrence of atrial fibrillation after electrical cardioversion in patients taking antiarrhythmic drugs?
Population
111 patients who underwent direct current cardioversion for symptomatic atrial fibrillation, taking…
Comparison
High C reactive protein concentration vs Low C reactive protein concentration
Design
Cohort
Follow-up
mean 76 days
Authors
Discussion
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Member takes
Implication
Elevated CRP may flag higher AF recurrence risk after cardioversion; leaves open whether targeting inflammation improves outcomes.
Study Design
Type
Cohort (n=111)
Structured PICO
Does a high C reactive protein concentration predict recurrence of atrial fibrillation after electrical cardioversion in patients taking antiarrhythmic drugs?
P
Population
111 patients taking antiarrhythmic drugs who underwent direct current cardioversion for symptomatic atrial fibrillation, followed for a mean of 76 days.
E
Exposure
High C reactive protein (CRP) concentration (upper 50th centile)
C
Comparator
Low C reactive protein (CRP) concentration (lower 50th centile)
O
Outcome
Recurrence of atrial fibrillationhard clinical
Main Result
Hazard Ratio: 2 (95% CI 1.2–3.2)
Absolute Event Rate: 80% vs 55%
p-value: p=0.007
Elevated baseline CRP levels are independently associated with a higher risk of atrial fibrillation recurrence after electrical cardioversion, suggesting a role for inflammation in drug-resistant AF.
Cite This Study
Wazni et al. (2005) conducted a cohort in symptomatic atrial fibrillation (n=111). High C reactive protein (CRP) concentration (upper 50th centile) vs. Lower 50th centile of CRP was evaluated on recurrence of atrial fibrillation (HR 2.0, 95% CI 1.2 to 3.2, p=0.007). High CRP concentration was associated with increased atrial fibrillation recurrence after electrical cardioversion compared to lower CRP concentration (HR 2.0; 95% CI 1.2-3.2; p=0.007).