What question did this study set out to answer?

To assess whether preventive antimalarial treatment reduces Plasmodium falciparum infection, anaemia, and clinical malaria while curbing transmission among school-aged children in sub-Saharan Africa.

October 23, 2020The Lancet Global HealthOpen Access

Preventive malaria treatment among school-aged children in sub-Saharan Africa: a systematic review and meta-analyses

View Full Paper

Ask AI

Bookmark

Authors

LCLauren M. CoheeUniversity of Maryland, Baltimore COCharles OpondoUniversity of London SCSiân E. ClarkeUniversity of London

Discussion

Member takes

Implication

Systematic review and meta-analysis demonstrates reduced infection, anaemia, and clinical malaria in school-aged children, highlighting chemoprevention as a viable tool for community control.

Key Points

To assess whether preventive antimalarial treatment reduces Plasmodium falciparum infection, anaemia, and clinical malaria while curbing transmission among school-aged children in sub-Saharan Africa.
Searched PubMed, Embase, Cochrane CENTRAL, and ClinicalTrials.gov (1990–2018) for randomized trials evaluating antimalarial treatment in asymptomatic children aged 5–15 years in sub-Saharan Africa.
Identified 13 randomized trials (N=16,309) for study-level meta-analysis and pooled individual participant data (IPD) from 11 trials (N=15,658) using hierarchical generalized linear models.
In IPD meta-analysis, preventive treatment reduced P falciparum prevalence (adjusted RR [ARR] 0.46, 95% CI 0.40–0.53; p<0.0001; 11 studies) and anaemia (ARR 0.85, 95% CI 0.77–0.92; p<0.0001; 11 studies).
Preventive therapy halved the risk of subsequent clinical malaria across transmission settings (ARR 0.50, 95% CI 0.39–0.60; p<0.0001; 4 studies; 1,815 individuals).
A marginal improvement in cognitive function was observed in children older than 10 years (adjusted mean difference 0.36, 95% CI 0.01–0.71; p=0.044; 5 studies), with no significant effect across all ages combined.

Cite This Study

Cohee et al. (2020) studied this question.

synapsesocial.com/papers/6a122ec7e407b26696345bc2 https://doi.org/10.1016/s2214-109x(20)30325-9

View Full Paper

Ask AI

Bookmark

Implication

Systematic review and meta-analysis demonstrates reduced infection, anaemia, and clinical malaria in school-aged children, highlighting chemoprevention as a viable tool for community control.

Preventive malaria treatment among school-aged children in sub-Saharan Africa: a systematic review and meta-analyses

Discussion

Member takes

Implication

Key Points

Cite This Study

Preventive malaria treatment among school-aged children in sub-Saharan Africa: a systematic review and meta-analyses

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider