Key result
Non-smoking is linked to ~28% higher FMD, while longer cessation correlates with better vascular function.
Why the study?
Smoking predisposes to endothelial dysfunction, but smoking cessation is thought to have a beneficial effect on cardiovascular risk, prompting evaluation of its effect on vascular function.
Does smoking cessation improve vascular function as measured by Flow-Mediated Dilation in adult men?
Cross-Sectional (n=45)
Yes
Does smoking cessation improve vascular function as measured by Flow-Mediated Dilation in adult men?
Smoking cessation improves vascular function and arterial compliance compared to active smoking, supporting its role in cardiovascular disease prevention.
Answers are grounded in this paper and cite their sources.
Cessation duration was associated with better FMD in this cohort; leaves open causal effects on vascular function.
Smoking predisposes to endothelial dysfunction; however smoking cessation would have a beneficial effect oncardiovascular risk. The objective of this study was to evaluate the effect of smoking cessation on vascular function.Methods: This is a comparative, prospective, descriptive, and multicenter study, carried out between March 2018and April 2021 at two Health Services of the National Gendarmerie and at the Laboratory of Physiology andFunctional Explorations of the Faculty of Medicine in Dakar, Senegal. The population included 45 consenting adultmen, divided into 3 groups: active smokers, weaned smokers, and non-smokers. We assessed vascular functionusing the Flow Mediated Dilation (FMD) technique, which consisted of measuring the diameter of the humeralartery at rest and then every 30 seconds after its occlusion.Results: Non-smokers showed better humeral artery dilation at T1 (30 seconds after occlusion release) with ahigher mean FMD than the other 2 groups (p = 0.0007). In addition, FMD kinetics showed that control subjects aswell as weaned subjects had better arterial compliance (p < 0.05) compared to active smokers. FMD1 values werepositively correlated with smoking cessation duration (p = 0.0411; R2 = 0.3374).Conclusion: Our results showed that stopping smoking improves vascular function and thus constitutes ameans of preventing cardiovascular diseases, hence the need to promote smoking cessation in Africa and moreparticularly in Senegal.
No takes yet. Share an insight, caveat, or question.
Ba-Diop et al. (2024) conducted a cross-sectional in Smoking (n=45). Smoking cessation vs. Active smokers and non-smokers was evaluated on Mean Flow Mediated Dilation (FMD) at T1 (30 seconds after occlusion release) (p=0.0007). Non-smokers demonstrated higher mean flow-mediated dilation at 30 seconds post-occlusion compared to active and weaned smokers, and smoking cessation duration positively correlated with improved vascular function.
Synapse has enriched 10 related papers. Consider them for comparative context: