Key result
Clinical CMR advances sequential cardiac fibrosis assessment in mouse models to facilitate reverse translation.
Why the study?
Improving the application of CMR in mouse models of cardiac fibrosis can advance the understanding of underlying mechanisms and improve assessment of anti-fibrotic therapy safety and efficacy.
Design
Review
Authors
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Supports sequential fibrosis assessment in mouse models with clinical CMR; leaves open prospective validation for anti-fibrotic therapy development.
This review highlights the technical advancements in CMR for assessing cardiac fibrosis in mouse models, emphasizing its role in reverse translation and the discovery of anti-fibrotic therapies.
Chen et al. (2023) conducted a review in Cardiac fibrosis. Cardiovascular magnetic resonance (CMR) imaging was evaluated. Cardiovascular magnetic resonance imaging techniques established clinically have advanced the sequential assessment of cardiac fibrosis in experimental mouse models, facilitating reverse translation.
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