Vitamin D Deficiency and Risk of Cardiovascular Disease
Key result
Vitamin D deficiency linked to ~62% greater risk of incident CV events.
- HR 1.62
- 95% CI 1.11 to 2.36
- P=0.01
- n=1,739
Why the study?
A growing body of evidence suggests vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking.
Does Vitamin D deficiency increase the risk of first cardiovascular event in individuals without prior cardiovascular disease?
Population
1739 Framingham Offspring Study participants without prior cardiovascular disease, mean age 59 years, 55% women, all white
Comparison
Vitamin D deficiency (25-OH D < 15 ng/mL or < 10 ng/mL) vs 25-OH D ≥ 15 ng/mL
Design
Prospective cohort study
Follow-up
Mean 5.4 years
Authors
Discussion
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Member takes
Implication
Low vitamin D levels were associated with incident CVD; hypothesis-generating and should not yet change practice.
Study Design
Type
Cohort (n=1,739)
Structured PICO
Does Vitamin D deficiency increase the risk of first cardiovascular event in individuals without prior cardiovascular disease?
P
Population
1,739 white adults (mean age 59 years, 55% women) without prior cardiovascular disease, followed for a mean of 5.4 years.
E
Exposure
Vitamin D deficiency (25-OH D < 15 ng/mL or < 10 ng/mL)
C
Comparator
25-OH D ≥ 15 ng/mL
O
Outcome
First cardiovascular eventcomposite
Main Result
Hazard Ratio: 1.62 (95% CI 1.11–2.36)
p-value: p=0.01
Vitamin D deficiency is associated with a significantly increased risk of incident cardiovascular events, particularly in individuals with hypertension.
Cite This Study
Wang et al. (2008) conducted a cohort in without prior cardiovascular disease (n=1,739). Vitamin D deficiency (25-OH D < 15 ng/mL) vs. 25-OH D ≥ 15 ng/mL was evaluated on incident cardiovascular events (HR 1.62, 95% CI 1.11 to 2.36, p=0.01). Vitamin D deficiency (<15 ng/mL) was associated with an increased risk of incident cardiovascular events compared with levels ≥15 ng/mL (HR 1.62; 95% CI 1.11-2.36; P=0.01).